In order to study and evaluate drought stress indices on yield, grain yield components, oil yield, seed oil percentage and sesame grain water use efficiency, a field study was carried out as split plots in randomized completely block design with three replications in 2018-2019 in Behbahan Agricultural Research Station. The main factor was the amount of irrigation water at four levels (40, 60, 80 and 100% of crop water requirement) that was applied by drip irrigation system since the beginning of flowering stage and the sub factor was sesame varieties including Darab1 and Dashtestan2 cultivars. The average applied water in 40, 60, 80 and 100% of crop water requirement treatments and also in control treatment (surface irrigation) were measured to be 350, 414, 478, 542 and 651 mm, respectively. The comparison of average water use efficiencies in different treatments of sesame seeds) for Darab1 cultivar with 100% crop 3showed a high value (0. 240 kg/mwater requirement, identifying as superior treatment. Also, the results of Pearson correlation coefficient showed by increasing plant height, number of seed in capsule, number of capsule per plant, 1000-seed weight, volume of applied water, the seed oil yield and water use efficiency increase. Finally, due to lower values of SSI and TOL indices and higher values of STI, MP and GMP indices in Darab1 variety compared to Dashtestan2 variety, Darab1 variety could be introduced as superior treatment in term of drought stress.